IGF1R-beta (AA 1101-1367) anticorps

N° du produit ABIN969207

Cet anticorps anti- est un anticorps Souris Monoclonal détectant dans ELISA et IHC. Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour IGF1R-beta (AA 1101-1367) anticorps (ABIN969207)

Antigène: IGF1R-beta

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: ELISA, Immunohistochemistry (IHC)

Clone: 3G5C1

Détail du produit

Épitope: AA 1101-1367

Fonction: IGF1R-Beta Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Référence

Zhu, Jiang, Thompson: "Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas." dans: Carcinogenesis, Vol. 24, Issue 7, pp. 1225-31, (2003) (PubMed).

Ling, Maile, Clemmons et al.: "Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth ..." dans: Molecular endocrinology (Baltimore, Md.), Vol. 17, Issue 9, pp. 1824-33, (2003) (PubMed).

Détail du antigène

Antigène: IGF1R-beta

Sujet: IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

Poids moléculaire: 96 kDa

UniProt: P08069